You can play around with a lot of things on your website, but don’t mess with convention. There are several things which people just expect on an everyday website, even if these things don’t always seem essential. Examples include a logo at the top (usually on the left) which can be clicked to get back to the site’s home page. The search box usually lives top right, even if it might make sense grouped with the site navigation. And the “About Us” page, even if it’s a lot more than just about you, really ought to be labelled “About Us”.
There are dozens of other conventions (this respected set comes from 2001 and nearly all of the suggestions still apply), and of course most sites will break a few rules. But don’t set out to break them just to be clever. Your visitors will get irritated and won’t thank you for it.